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BRINTELLIX is an immediate-release tablet for oral administration that contains the beta (β)
polymorph of vortioxetine hydrobromide (HBr), an antidepressant. Vortioxetine HBr is known
chemically as 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine, hydrobromide. The empirical
formula is C18H22N2S, HBr with a molecular weight of 379.36 g/mol.

Some of the common effects of vortioxetine include diarrhea, dry mouth, nausea, constipation,
flatulence, dizziness, and sexual dysfunction.

Vortioxetine or Brintellix pills is also a serotonin modulator and stimulator.
Brintellix (vortioxetine) is an antidepressant used to treat major depressive disorder (MDD).

BRINTELLIX (vortioxetine) Structural Formula Illustration
Vortioxetine HBr is a white to very slightly beige powder that is slightly soluble in water.

Each BRINTELLIX tablet contains 6.355 mg, 12.71 mg, 19.065 mg, or 25.42 mg of vortioxetine HBr
equivalent to 5 mg, 10 mg, 15 mg, or 20 mg of vortioxetine, respectively. The inactive ingredients in
BRINTELLIX tablets include mannitol, microcrystalline cellulose, hydroxypropyl cellulose, sodium
starch glycolate, magnesium stearate and film coating which consists of hypromellose, titanium
dioxide, polyethylene glycol 400, iron oxide red (5 mg, 15 mg, and 20 mg) and iron oxide yellow (10
mg and 15 mg).
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